Infographics are a welcome challenge--to visualize the heart behind statistics and information. I use a variety of styles to suit the topic, but generally work in Adobe Illustrator so that the vector illustrations can be scaled and moved for reuse in many contexts. For more painterly styles, I use Adobe Photoshop.
All of these infographics appeared first in print format in our quarterly Newsletters and Annual Report, at or slightly under 11"x17". They were later revised for distribution in other formats.